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      AAV包裝
      發布時間:2022-07-27   瀏覽:2111次

        1.AAV病毒載體有CMV(全身表達)、CAG(全身表達)、TBG(肝臟特異性)、Insulin(胰島Beta細胞特異性)、CK8(肌肉特異性)、tMCK(肌肉特異性)、Adiponectin(脂肪細胞特異性)、Syn(神經特異性)、CaMKIIa(神經特異性)等,根據需要可包裝對特定組織或細胞感染的AAV,用于表達目的基因。

        2.熒光蛋白標記載體:具有表達GFP、mCherry等AAV表達載體。

        3.具有靶向編輯基因AAV載體系統:CRISPR/Cas9(sgRNA)介導的基因編輯系統和shRNA介導的基因敲減系統。


      參考文獻

      1. Wang RR et al, (2022) Dietary intervention preserves β cell function in mice through CTCF-mediated transcriptional reprogramming. Journal of Experimental Medicine. IF: 14.41, (AAV)

      2. Qiao J et al (2022) A distinct role of STING in regulating glucose homeostasis through insulin sensitivity and insulin secretion. PNAS. IF=11.2, (AAV)

      3. Ji F et al (2022) Blocking hepatocarcinogenesis by a cytochrome P450 family member with female-preferential expression. Gut. IF=23, (AAV)

      4. Ma XR et al (2022) Restoring nuclear entry of Sirtuin 2 in oligodendrocyte progenitor cells promotes remyelination during ageing. Nature Communications. IF=14.9, (慢病毒)

      5. Wang RR et al, (2022) Dietary intervention preserves β cell function in mice through CTCF-mediated transcriptional reprogramming. Journal of Experimental Medicine. IF: 14.41, (AAV)

      6. Xu Z et al, (2022) Disuse-associated loss of the protease LONP1 in muscle impairs mitochondrial function and causes reduced skeletal muscle mass and strength. Nature Communications. IF: 14.9, (AAV)

      7. He S et al, (2021) IRE1α regulates skeletal muscle regeneration through Myostatin mRNA decay. J Clin Invest. IF: 15.86, (AAV)

      8. Wang J et al, (2021) Leukocyte cell-derived chemotaxin 2 promotes the development of nonalcoholic fatty liver disease through STAT-1 pathway in mice. Liver International. IF: 5.17, (AAV)

      9. Liu T et al, (2020) BAF60a deficiency uncouples chromatin accessibility and cold sensitivity from white fat browning. Nature Communications. IF=12.35, (逆轉錄病毒, AAV)

      10. Hu Z et al, (2019) CREBZF as a key Regulator of STAT3 Pathway in the Control of Liver Regeneration in Mice. Hepatology. IF=14.08, (腺病毒,AAV)

      11. Wang X et al, (2019) The zinc transporter Slc39a5 controls glucose sensing and insulin secretion in pancreatic β-cells via Sirt1- and Pgc-1α-mediated regulation of Glut2. Protein Cell. IF=6.228, (腺病毒)

      12. Liu L et al, (2019) Coupling of COPII vesicle trafficking to nutrient availability by the IRE1α-XBP1s axis. PNAS. June 11; 116 (24) 11776-11785. IF=9.504, (AAV,腺病毒)

      13. Li Y et al, (2019) MiR-223 is essential for maintaining functional β-cell mass during diabetes through targeting unique bipartite Foxo1 and Sox6 pathways. Journal of Biological Chemistry. IF=4.01, (腺病毒)

      14. Zhao XY et al, (2018) Long noncoding RNA licensing of obesity-linked hepatic lipogenesis and NAFLD pathogenesis. Nature Communications. IF=12.35, (AAV,腺病毒)

      15. Zhang F et al, (2018) Hepatic CREBZF Couples Insulin to Lipogenesis by Inhibiting Insig activity and Contributes to Hepatic Steatosis in Diet-Induced Insulin-Resistant Mice. Hepatology. IF=14.079, (腺病毒)

      16. Guo L et al, (2017) Hepatic neuregulin 4 signaling defines an endocrine checkpoint for steatosis-to-NASH progression. J Clin Invest. IF=12.28, (腺病毒,AAV)

      17. Meng ZX et al, (2018) Uncoupling exercise bioenergetics from systemic metabolic homeostasis by conditional inactivation of Baf60s in skeletal muscle. Diabetes. IF: 7.72, (逆轉錄病毒, 腺病毒)

      18. Zhang D et al, (2017) Lipogenic transcription factor ChREBP mediates fructose-induced metabolic adaptations to prevent hepatotoxicity. J Clin Invest. IF=12.28, (腺病毒)

      19. Meng ZX et al, (2017) Glucose sensing by skeletal myocytes couples nutrient signaling to systemic homeostasis. Molecular Cell. IF: 15.58, (逆轉錄病毒, 腺病毒)

       


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